The central role of biomolecular structure and biophysics in life science research provides the rationale for a program in Biomolecular Structure and Biophysics, focusing. Chemical and systems biology as applied to drug discovery; design, synthesis, and. University of Zurich » Ph.D. Program Biomolecular Structure and Mechanism » Research Groups Home . Protein design, enzymology and capsid engineering Takashi Ishikawa (PSI) Electron cryo-microscopy and tomography Martin Jinek (UZH). Biomolecular Structure and Interactions - Chemistry. Function, Mechanisms, Design and Recognition. The research in this focus area is involved with the structures of biological macromolecules and their complexes as well as the interactions of molecules in cells that control all regulation from replication to metabolism. During the last five year period the Department has established a Georgia Research Alliance- NIH- NSF funded biomolecular interaction core facility. The core facility also has biosensor- surface plasmon resonance instruments for real time detection of binding affinities and kinetics and well as microcalorimeters for analysis of biomolecular interactions. A small sampling of the projects in this area, all of which have received external funding in the last five years, will give an overview of the research. Jenny Yang. In order to understand these critically important biological processes. The key determinants for Ca. Her group carries out both crystallographic and biochemical analysis and interaction studies on proteins implicated in disease. The Tcl. 1 oncoprotein and HIV protease have been recently investigated. The interaction of HIV protease with novel inhibitors is being studies by both structural; and interaction methods. The long range objective of these studies is to develop new therapeutic agents to treat AIDS and cancer. Dr. David Wilson.
The biomolecular interactions group also has a very strong base of research in the nucleic acid area. David Wilson, in collaboration with the drug design and synthesis team of. David Boykin. The information from the interaction as well as QSAR and structural studies is used by the Boykin group in the design of new compounds which have a high potential of improved activity. This effort has already resulted in a clinical candidate which has passed both Phase I and II clinical trials with excellent results. The research of this group has also resulted in a number of fundamental advances in the understanding of nucleic acid molecular recognition. Dr. They are investigating the interaction of novel zinc finger proteins with the HIV- 1 RNA. They use a broad range of methods, but particularly NMR, to understand how engineered zinc finger proteins bind their RNA substrates. In order to improve the substrate- affinity they use NMR structural data for site directed mutagenesis experiments and structure guided phage display selection. Germann and Wilson are collaborating on structural studies to better understand the molecular basis of DNA minor groove recognition. Dr. Several of the designed compounds photocleave DNA with high efficiency under near physiological conditions of temperature and p. H. Because phenothiazines are activated by wavelengths of light transparent to most biological membranes, they possess a significant, major advantage over most other chromophores for applications in photodynamic cancer therapy. Dr. Huang’s laboratory is carrying out both the synthetic and x- ray crystallography parts of the project.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. Archives
December 2016
Categories |